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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3020
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lta
Name: lymphotoxin alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ltaincreases expressionISOLTA (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of LTA mRNAPMID:31059760 PMID:35811015
Ltaincreases expressionISOLta (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of LTA mRNA; Lipopolysaccharides results in increased expression of LTA proteinPMID:12057914 PMID:21135813 PMID:25843059
Ltamultiple interactionsISOLTA (Homo sapiens)6480464CTD[Acetaminophen co-treated with Lipopolysaccharides] affects the expression of LTA mRNA; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of LTA mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of LTA mRNA; [usnic acid co-treated with Lipopolysaccharides] results in decreased expression of LTA mRNAPMID:22777745 PMID:31059760 PMID:35811015
Ltamultiple interactionsISOLta (Mus musculus)6480464CTD3,4-dihydroxybenzohydroxamic acid affects the reaction [Lipopolysaccharides results in increased expression of LTA mRNA]PMID:25843059
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