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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2906
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcr2
Name: C-X-C motif chemokine receptor 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr2decreases expressionISOCXCR2 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of CXCR2 mRNA; Lipopolysaccharides results in decreased expression of CXCR2 proteinPMID:10950785 PMID:11531949 PMID:14997032 PMID:26111115 PMID:35811015
Cxcr2increases expressionISOCXCR2 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of CXCR2 proteinPMID:26111115
Cxcr2multiple interactionsISOCXCR2 (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CXCR2 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of CXCR2 mRNA; doramapimod inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CXCR2 protein]PMID:10950785 PMID:14997032 PMID:35811015
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