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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2898
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il4
Name: interleukin 4
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:107966480464CTDLipopolysaccharides results in decreased expression of IL4 mRNA

PMID:21867779, PMID:22024136
increases expressionISORGD:107966480464CTDLipopolysaccharides results in increased expression of IL4 protein

PMID:17400256, PMID:20851137, PMID:27568862
increases expressionISORGD:7363066480464CTDLipopolysaccharides results in increased expression of IL4 mRNA, Lipopolysaccharides results in increased expression of IL4 protein

PMID:19020770, PMID:29128401
increases secretionISORGD:7363066480464CTDLipopolysaccharides results in increased secretion of IL4 protein

PMID:20049214, PMID:20600710
multiple interactionsISORGD:107966480464CTD(+)-JQ1 compound inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of BCL6 protein], (+)-JQ1 compound inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of IRF8 protein], (+)-JQ1 compound inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of PAX5 protein], [CTH protein mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL4 mRNA, [CTH protein mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL4 protein, [Ibuprofen co-treated with Lipopolysaccharides] results in increased expression of IL4 protein, [IL4 protein co-treated with Lipopolysaccharides] results in increased expression of CHIL3 mRNA, [IL4 protein co-treated with Lipopolysaccharides] results in increased expression of RETNLA mRNA, [Lipopolysaccharides co-treated with IL4 protein] results in increased expression of ARG1 mRNA, [Lipopolysaccharides co-treated with IL4 protein] results in increased expression of BCL6 protein, [Lipopolysaccharides co-treated with IL4 protein] results in increased expression of CLEC7A mRNA, [Lipopolysaccharides co-treated with IL4 protein] results in increased expression of IL12B mRNA, [Lipopolysaccharides co-treated with IL4 protein] results in increased expression of IRF8 protein, [Lipopolysaccharides co-treated with IL4 protein] results in increased expression of MRC1 mRNA, [Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA, [Lipopolysaccharides co-treated with IL4 protein] results in increased expression of PAX5 protein, [Lipopolysaccharides co-treated with IL4] results in increased expression of ABL2 mRNA, [Selenium co-treated with Lipopolysaccharides co-treated with IL4 protein] results in decreased expression of IL1B mRNA, [Selenium co-treated with Lipopolysaccharides co-treated with IL4 protein] results in decreased expression of TNF mRNA, Berberine inhibits the reaction [Lipopolysaccharides results in decreased expression of IL4 mRNA], Chloroform promotes the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA], coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL4 protein], Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL4 protein], Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein], IL4 affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA], IL4 affects the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA], IL4 affects the reaction [Rosiglitazone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]], IL4 protein promotes the reaction [Lipopolysaccharides results in increased expression of SOCS1 mRNA], Lipopolysaccharides affects the reaction [IL4 protein results in increased expression of ABL2 mRNA], Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL4 mRNA], Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL4 protein], Lipopolysaccharides promotes the reaction [IL4 results in increased expression of SOCS1 mRNA], Progesterone inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of ARG1 mRNA], Progesterone inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of IL12B mRNA], Progesterone inhibits the reaction [[Lipopolysaccharides co-treated with IL4 protein] results in increased expression of NOS2 mRNA], Progesterone promotes the reaction [[IL4 protein co-treated with Lipopolysaccharides] results in increased expression of CHIL3 mRNA], Progesterone promotes the reaction [[IL4 protein co-treated with Lipopolysaccharides] results in increased expression of RETNLA mRNA]

PMID:17400256, PMID:17950491, PMID:19020770, PMID:21775527, PMID:21867779, PMID:21977998, PMID:22024136, PMID:25656449, PMID:27568862, PMID:29128401
multiple interactionsISORGD:7363066480464CTD[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with IL4 protein] affects the phosphorylation of STAT6 protein, [Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL13 protein co-treated with Nanotubes, Carbon co-treated with IL4 protein] affects the phosphorylation of STAT6 protein, [Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL4 protein co-treated with Nanotubes, Carbon] affects the phosphorylation of STAT6 protein, [Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with IL4 protein] affects the phosphorylation of STAT6 protein, [IL13 protein co-treated with IL4 protein co-treated with Nanotubes, Carbon] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein], [IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein], [IL4 protein co-treated with IL13 protein] inhibits the reaction [Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]], [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL4 protein, IL4 protein inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the secretion of IL1B protein], IL4 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein], IL4 protein inhibits the reaction [Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]], IL4 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN protein], Leflunomide inhibits the reaction [[IL13 protein co-treated with IL4 protein] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of and affects the activity of CASP1 protein]], Lipopolysaccharides inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD1A protein], Lipopolysaccharides promotes the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of TFRC protein], Mercuric Chloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL4 protein], Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of IL4 protein], sodium bisulfide inhibits the reaction [Lipopolysaccharides results in increased expression of IL4 mRNA], sodium bisulfide inhibits the reaction [Lipopolysaccharides results in increased expression of IL4 protein]

PMID:15698409, PMID:18390722, PMID:18437699, PMID:20049214, PMID:26091108, PMID:29128401, PMID:8777273, PMID:9722937
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.