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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2850
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr4
Name: 5-hydroxytryptamine receptor 4
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr4multiple interactionsISOHTR4 (Homo sapiens)6480464CTDHTR4 protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein]; HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]; HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; HTR4 protein promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]PMID:15802305
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