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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects localizationEXP 6480464CTDLipopolysaccharides affects the localization of ABCC2 proteinPMID:28842383
Abcc2decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of ABCC2 mRNAPMID:15205115 PMID:15205389 PMID:28842383
Abcc2multiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCC2 mRNA; GCG protein inhibits the reaction [Lipopolysaccharides affects the localization of ABCC2 protein]; GCG protein inhibits the reaction [Lipopolysaccharides results in decreased expression of ABCC2 mRNA]; GCG protein inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of ABCC2 protein]; Lipopolysaccharides affects the localization of and results in decreased expression of ABCC2 protein; Lipopolysaccharides results in decreased expression of and results in decreased activity of ABCC2 proteinPMID:12706339 PMID:25331106 PMID:28842383
Abcc2decreases activityISOAbcc2 (Mus musculus)6480464CTDLipopolysaccharides results in decreased activity of ABCC2 proteinPMID:14709616
Abcc2decreases expressionISOAbcc2 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of ABCC2 mRNAPMID:14709616 PMID:15312239 PMID:15313196 PMID:30633930
Abcc2decreases expressionISOABCC2 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of ABCC2 proteinPMID:15205115
Abcc2multiple interactionsISOAbcc2 (Mus musculus)6480464CTD[triptolide co-treated with Lipopolysaccharides co-treated with obeticholic acid] results in increased expression of ABCC2 mRNA; [triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCC2 mRNA; [triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCC2 proteinPMID:36328986
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