Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2286
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cbr1
Name: carbonyl reductase 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cbr1multiple interactionsISOCBR1 (Homo sapiens)6480464CTDCBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]PMID:25818598
Go Back to source page   Continue to Ontology report