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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Msr1
Name: macrophage scavenger receptor 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Msr1affects expressionISOMSR1 (Homo sapiens)6480464CTDLipopolysaccharides affects the expression of MSR1 mRNAPMID:28070326
Msr1increases expressionISOMsr1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of MSR1 mRNA; Lipopolysaccharides results in increased expression of MSR1 proteinPMID:10223745 PMID:22169119
Msr1multiple interactionsISOMSR1 (Homo sapiens)6480464CTDPlant Extracts affects the reaction [Lipopolysaccharides affects the expression of MSR1 mRNA]PMID:28070326
Msr1multiple interactionsISOMsr1 (Mus musculus)6480464CTD[Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of MSR1 mRNA]; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of MSR1 mRNA; [LLY-507 affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in decreased expression of MSR1 mRNA; [SMYD2 mRNA affects the susceptibility to [Lipopolysaccharides co-treated with IFNG protein]] which results in increased expression of MSR1 mRNA; Eicosapentaenoic Acid promotes the reaction [Lipopolysaccharides results in increased expression of MSR1 mRNA]PMID:22169119 PMID:29718165
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