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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352377
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL7
Name: C-C motif chemokine ligand 7
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL7increases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of CCL7 proteinPMID:32800949
CCL7multiple interactionsEXP 6480464CTD2'-hydroxyflavanone inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL7 protein]; [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of CCL7 protein; [S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of CCL7 mRNAPMID:18437699 PMID:32800949 PMID:35811015
CCL7increases expressionISOCcl7 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of CCL7 mRNAPMID:22169119 PMID:25890327 PMID:26582142 PMID:27339419 PMID:29471534
CCL7multiple interactionsISOCcl7 (Mus musculus)6480464CTD(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of CCL7 mRNA]; [procyanidin B3 co-treated with Eicosapentaenoic Acid] inhibits the reaction [Lipopolysaccharides results in increased expression of CCL7 mRNA]; cypermethrin promotes the reaction [Lipopolysaccharides results in increased expression of CCL7 mRNA]PMID:22169119 PMID:25890327 PMID:29471534
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