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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349807
Species: Homo sapiens
RGD Object: Gene
Symbol: IFNGR1
Name: interferon gamma receptor 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IFNGR1multiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of IFNGR1 mRNAPMID:21878375
IFNGR1decreases expressionISOIfngr1 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of IFNGR1 mRNAPMID:22185406
IFNGR1multiple interactionsISOIfngr1 (Mus musculus)6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]; Quercetin inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]PMID:22185406
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