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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of HSPA1A proteinPMID:19675143
HSPA1Amultiple interactionsEXP 6480464CTD[usnic acid co-treated with Lipopolysaccharides] results in increased expression of HSPA1A mRNAPMID:22777745
HSPA1Amultiple interactionsISOHspa1a (Rattus norvegicus)6480464CTD[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HSPA1A mRNAPMID:16415329
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