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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318176
Species: Mus musculus
RGD Object: Gene
Symbol: Rora
Name: RAR-related orphan receptor alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Roraaffects response to substanceEXP 6480464CTDRORA protein affects the susceptibility to LipopolysaccharidesPMID:28698385
Roraincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of RORA mRNA; Lipopolysaccharides results in increased expression of RORA proteinPMID:28698385
Roramultiple interactionsEXP 6480464CTD[RORA protein affects the susceptibility to Lipopolysaccharides] which affects the expression of IL1A; [RORA protein affects the susceptibility to Lipopolysaccharides] which affects the expression of IL1B; [RORA protein affects the susceptibility to Lipopolysaccharides] which affects the expression of TNFPMID:28698385
Roraincreases expressionISORORA (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of RORA mRNAPMID:35811015
Roramultiple interactionsISORORA (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of RORA mRNAPMID:35811015
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