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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307843
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pias1
Name: protein inhibitor of activated STAT, 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pias1multiple interactionsISOPias1 (Mus musculus)6480464CTDPIAS1 protein inhibits the reaction [MIR483 mRNA promotes the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; PIAS1 protein inhibits the reaction [MIR483 mRNA promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]]; PIAS1 protein inhibits the reaction [MIR483 mRNA promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]]; PIAS1 protein inhibits the reaction [MIR483 mRNA promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; PIAS1 protein inhibits the reaction [MIR483 mRNA promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]PMID:32062619
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