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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307040
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k4
Name: mitogen activated protein kinase kinase 4
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k4increases phosphorylationISOMAP2K4 (Homo sapiens)150429951RGDlipopolysaccharide increases phosphorylation of MAP2K4 protein in the pulmonary alveolus epithelium 
Map2k4increases activityISOMap2k4 (Mus musculus)6480464CTDLipopolysaccharides results in increased activity of MAP2K4 proteinPMID:20589745
Map2k4increases phosphorylationISOMAP2K4 (Homo sapiens)6480464CTDLipopolysaccharides results in increased phosphorylation of MAP2K4 proteinPMID:21112663
Map2k4increases phosphorylationISOMap2k4 (Mus musculus)6480464CTDLipopolysaccharides results in increased phosphorylation of MAP2K4 proteinPMID:21548916
Map2k4multiple interactionsISOMAP2K4 (Homo sapiens)6480464CTDMYD88 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein]; TLR2 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein]PMID:21112663
Map2k4multiple interactionsISOMap2k4 (Mus musculus)6480464CTD[Manganese co-treated with Lipopolysaccharides] results in increased activity of and results in increased phosphorylation of MAP2K4 protein; aciculatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K4 protein]; Lipopolysaccharides promotes the reaction [Manganese results in increased activity of MAP2K4 protein]; Manganese promotes the reaction [Lipopolysaccharides results in increased activity of MAP2K4 protein]PMID:20589745 PMID:21548916
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