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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10786
Species: Mus musculus
RGD Object: Gene
Symbol: Il15
Name: interleukin 15
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il15increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of IL15 mRNAPMID:10975854 PMID:25472953 PMID:26582142
Il15increases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of IL15 proteinPMID:32800949
Il15multiple interactionsEXP 6480464CTD2'-hydroxyflavanone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL15 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 mRNA]PMID:25472953 PMID:32800949
Il15increases expressionISOIL15 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of IL15 mRNA; Lipopolysaccharides results in increased expression of IL15 proteinPMID:27568862 PMID:35811015
Il15increases secretionISOIL15 (Homo sapiens)6480464CTDLipopolysaccharides results in increased secretion of IL15 proteinPMID:32800949
Il15multiple interactionsISOIL15 (Homo sapiens)6480464CTD[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IL15 protein; coagulin-L inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 protein]; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 mRNA]PMID:18437699 PMID:27568862 PMID:35811015
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