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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionEXP 6480464CTDLipopolysaccharides affects the expression of BCL2 proteinPMID:30261164
Bcl2decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of BCL2 proteinPMID:23170834 PMID:27523796 PMID:30776389 PMID:32687258 PMID:36056792 PMID:36169195 PMID:37436358
Bcl2increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of BCL2 proteinPMID:21299906
Bcl2multiple interactionsEXP 6480464CTD2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; [Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of BCL2 protein; [Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of BCL2 protein modified form; [Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of BCL2 protein; [Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA; [TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2 mRNA; AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]; baicalein inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of BCL2 protein modified form]; Carticaine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; CASP1 protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]; CASP1 protein affects the reaction [AHR protein affects the reaction [[Silicon Dioxide co-treated with Lipopolysaccharides] results in decreased expression of BCL2 mRNA]]; catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; epigallocatechin gallate inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; gentiopicroside inhibits the reaction [[Galactosamine co-treated with Lipopolysaccharides] results in decreased expression of BCL2 protein]; MYD88 protein affects the reaction [[TNFAIP3 gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of BCL2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; palmatine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; sesamol affects the reaction [Lipopolysaccharides affects the expression of BCL2 protein]; Silymarin inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in decreased expression of BCL2 protein modified form]; Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of BCL2 protein]; zinc protoporphyrin inhibits the reaction [2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]PMID:10205001 PMID:20558151 PMID:20850421 PMID:22273745 PMID:23170834 PMID:24453940 PMID:27523796 PMID:30261164 PMID:30776389 PMID:32687258 PMID:36056792 PMID:36169195 PMID:37436358
Bcl2affects expressionISOBcl2 (Rattus norvegicus)6480464CTDLipopolysaccharides affects the expression of BCL2 mRNAPMID:21127968
Bcl2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTDLipopolysaccharides results in decreased expression of BCL2 proteinPMID:23200736 PMID:24973090 PMID:25557508 PMID:30084861 PMID:31486215 PMID:34859534 PMID:35110471
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of BCL2 proteinPMID:11805214 PMID:16822680 PMID:23063943 PMID:34687491 PMID:35331853 PMID:37209277 PMID:37436358 PMID:37483096
Bcl2increases expressionISOBcl2 (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of BCL2 proteinPMID:12704018 PMID:21504754 PMID:21586279
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of BCL2 mRNA; Lipopolysaccharides results in increased expression of BCL2 proteinPMID:20166893 PMID:25725100
Bcl2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; [Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein; Apigenin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Bezafibrate inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 protein]; ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; MIR17 mRNA affects the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; PTEN protein inhibits the reaction [ferulic acid inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; Sialic Acids inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; tetramethylpyrazine inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 protein]; Tigecycline inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]PMID:12704018 PMID:21477647 PMID:21586279 PMID:23200736 PMID:24973090 PMID:25557508 PMID:31486215 PMID:34859534 PMID:35110471
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; [Dehydroascorbic Acid co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein; adenosine-3',5'-cyclic phosphorothioate inhibits the reaction [Bucladesine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; alpha-Tocopherol affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Bucladesine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Cilostazol inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; FANCA mRNA alternative form affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; KR-31612 affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; lipoxin A4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; MIR17 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxymethyl-2H-benzopyran-4-yl)-N'-benzylguanidine inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; NEAT1 affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; PCNA affects the reaction [FANCA mRNA alternative form affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; puerarin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; SIRT1 protein affects the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; TLR4 protein inhibits the reaction [NEAT1 affects the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; TRPM7 protein inhibits the reaction [MIR17 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]PMID:11805214 PMID:16822680 PMID:20166893 PMID:23063943 PMID:25725100 PMID:34687491 PMID:35331853 PMID:37209277 PMID:37436358 PMID:37483096
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