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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10183
Species: Mus musculus
RGD Object: Gene
Symbol: Aqp4
Name: aquaporin 4
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp4affects response to substanceEXP 6480464CTDAQP4 protein affects the susceptibility to LipopolysaccharidesPMID:20615459
Aqp4multiple interactionsEXP 6480464CTD[AQP4 protein affects the susceptibility to Lipopolysaccharides] which affects the abundance of Reactive Oxygen Species; [AQP4 protein affects the susceptibility to Lipopolysaccharides] which affects the expression of CYP2E1 mRNA; allyl sulfide inhibits the reaction [AQP4 protein affects the susceptibility to Lipopolysaccharides]PMID:20615459
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