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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732222
Species: Mus musculus
RGD Object: Gene
Symbol: Gsr
Name: glutathione reductase
Acc ID: CHEBI:16410
Term: pyridoxamine
Definition: A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 3, an aminomethyl group at position 4, a hydroxymethyl group at position 5 and a methyl group at position 2. The 4-aminomethyl form of vitamin B6, it is used (in the form of the hydrochloride salt) for treatment of diabetic nephropathy.
Chemical ID: MESH:D011733
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityISOGsr (Rattus norvegicus)6480464CTDPyridoxamine results in decreased activity of GSR proteinPMID:24831520
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