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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:16363
Term: alpha-santonin
Definition: A santonin that is 3a,5,5a,9b-tetrahydronaphtho[1,2-b]furan-2,8(3H,4H)-dione substituted by methyl groups at positions 3, 5a and 9.
Chemical ID: MESH:D012500
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISORGD:691056480464CTDSantonin results in increased activity of NR1I2 protein

PMID:25455453
Nr1i2multiple interactionsISORGD:691056480464CTD[Santonin results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA

PMID:25455453
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