GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp7a1 | multiple interactions | EXP | | 6480464 | CTD | [Cholesterol, Dietary co-treated with Cholic Acid] results in decreased activity of CYP7A1 protein; [Cholesterol, Dietary co-treated with Cholic Acid] results in decreased expression of CYP7A1 mRNA | PMID:14684380 | Cyp7a1 | decreases expression | ISO | Cyp7a1 (Mus musculus) | 6480464 | CTD | Cholic Acid results in decreased expression of CYP7A1 mRNA | PMID:12072388 PMID:15694933 PMID:17521389 PMID:20671298 PMID:25582706 | Cyp7a1 | decreases expression | ISO | CYP7A1 (Homo sapiens) | 6480464 | CTD | Cholic Acid results in decreased expression of CYP7A1 mRNA | PMID:25055961 | Cyp7a1 | multiple interactions | ISO | Cyp7a1 (Mus musculus) | 6480464 | CTD | [Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA | PMID:22540009 | |
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