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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:16359
Term: cholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid bearing three alpha-hydroxy substituents at position 3, 7 and 12.
Chemical ID: MESH:D019826
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1multiple interactionsEXP 6480464CTD[Cholesterol, Dietary co-treated with Cholic Acid] results in decreased activity of CYP7A1 protein; [Cholesterol, Dietary co-treated with Cholic Acid] results in decreased expression of CYP7A1 mRNAPMID:14684380
Cyp7a1decreases expressionISOCyp7a1 (Mus musculus)6480464CTDCholic Acid results in decreased expression of CYP7A1 mRNAPMID:12072388 PMID:15694933 PMID:17521389 PMID:20671298 PMID:25582706
Cyp7a1decreases expressionISOCYP7A1 (Homo sapiens)6480464CTDCholic Acid results in decreased expression of CYP7A1 mRNAPMID:25055961
Cyp7a1multiple interactionsISOCyp7a1 (Mus musculus)6480464CTD[Cholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNAPMID:22540009
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