Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:16348
Term: 3-nitropropanoic acid
Definition: A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Chemical ID: MESH:C015392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTD3-nitropropionic acid results in decreased phosphorylation of AKT1 proteinPMID:29753867 PMID:36509115
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTDN(6)-cyclohexyladenosine inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]; Topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein]PMID:29753867 PMID:36509115
Go Back to source page   Continue to Ontology report