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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:16348
Term: 3-nitropropanoic acid
Definition: A C-nitro compound that is propanoic acid in which one of the methyl hydrogens has been replaced by a nitro group.
Chemical ID: MESH:C015392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATdecreases activityISOCat (Rattus norvegicus)6480464CTD3-nitropropionic acid results in decreased activity of CAT proteinPMID:20305041 PMID:21945202 PMID:25445565 PMID:27206696 PMID:37116597
CATdecreases expressionISOCat (Rattus norvegicus)6480464CTD3-nitropropionic acid results in decreased expression of CAT proteinPMID:20448265
CATmultiple interactionsISOCat (Rattus norvegicus)6480464CTD3-nitropropionic acid affects the reaction [[lead acetate results in increased abundance of Lead] affects the reaction [Ethanol affects the expression of CAT protein]]; 3-nitropropionic acid affects the reaction [[lead acetate results in increased abundance of Lead] which affects the expression of CAT protein]; 3-nitropropionic acid affects the reaction [Ethanol affects the expression of CAT protein]; Cyclosporine inhibits the reaction [3-nitropropionic acid results in decreased expression of CAT protein]; naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Nitric Oxide promotes the reaction [Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Nitric Oxide promotes the reaction [Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]]; Sertraline inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone analog inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; thymoquinone inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; trandolapril inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; Venlafaxine Hydrochloride inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]PMID:20305041 PMID:20448265 PMID:21945202 PMID:25445565 PMID:27206696 PMID:31550440
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