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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606587
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP19A1
Name: cytochrome P450 family 19 subfamily A member 1
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP19A1decreases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDDihydrotestosterone results in decreased expression of CYP19A1 mRNA; Dihydrotestosterone results in decreased expression of CYP19A1 proteinPMID:22948218
CYP19A1increases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDDihydrotestosterone results in increased expression of CYP19A1 mRNA; Dihydrotestosterone results in increased expression of CYP19A1 proteinPMID:15525594 PMID:21273442
CYP19A1multiple interactionsISOCyp19a1 (Rattus norvegicus)6480464CTDFSHB protein inhibits the reaction [Dihydrotestosterone results in decreased expression of CYP19A1 protein]PMID:22948218
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