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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350637
Species: Homo sapiens
RGD Object: Gene
Symbol: TOP2B
Name: DNA topoisomerase II beta
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TOP2Bmultiple interactionsEXP 6480464CTDTOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of KLK2 mRNA], TOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA], TOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of SLC45A3 mRNA], TOP2B protein promotes the reaction [Dihydrotestosterone results in increased expression of TMPRSS2 mRNA]

PMID:20601956
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.