GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NFE2L2 | decreases response to substance | EXP | | 6480464 | CTD | NFE2L2 protein results in decreased susceptibility to Lithocholic Acid | PMID:17724089 | NFE2L2 | multiple interactions | EXP | | 6480464 | CTD | [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of FTL mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA; Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of and affects the localization of NFE2L2 protein]; Lithocholic Acid results in decreased expression of and results in decreased activity of NFE2L2 protein; Lithocholic Acid results in increased expression of and results in increased localization of and results in increased activity of NFE2L2 protein; S-Adenosylmethionine inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]]; Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein]; VDR protein affects the reaction [Lithocholic Acid inhibits the reaction [TNF protein results in decreased expression of NFE2L2 protein]] | PMID:17724089 PMID:20146260 PMID:31472180 | NFE2L2 | decreases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Lithocholic Acid results in decreased expression of NFE2L2 mRNA; Lithocholic Acid results in decreased expression of NFE2L2 protein | PMID:29794447 | NFE2L2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of GCLM mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Lithocholic Acid results in increased activity of NFE2L2 protein] which results in increased expression of TXN1 mRNA; Lithocholic Acid results in increased localization of and results in increased activity of NFE2L2 protein; NFE2L2 protein inhibits the reaction [Lithocholic Acid results in increased expression of GSTA4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCA1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC2 protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC3 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC5 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCG2 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of GSTM1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of TXNRD1 protein]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 mRNA]; Vardenafil Dihydrochloride inhibits the reaction [Lithocholic Acid results in decreased expression of NFE2L2 protein] | PMID:17724089 PMID:20977460 PMID:29794447 | | ||||||||||||||||||||||
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