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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1623761
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc4
Name: ATP-binding cassette, sub-family C member 4
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc4decreases expressionEXP 6480464CTDLithocholic Acid results in decreased expression of ABCC4 mRNAPMID:17256725
Abcc4increases expressionEXP 6480464CTDLithocholic Acid results in increased expression of ABCC4 mRNAPMID:18032408 PMID:20977460 PMID:23034213
Abcc4multiple interactionsEXP 6480464CTD1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; [Lithocholic Acid co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene] results in increased expression of ABCC4 protein; [Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC4 protein; Lithocholic Acid promotes the reaction [NR1H3 protein results in increased expression of ABCC4 mRNA]; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC4 mRNA]PMID:17256725 PMID:18032408 PMID:20977460 PMID:23034213
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