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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDLithocholic Acid results in decreased expression of UGT1A1 mRNA

PMID:19196849
multiple interactionsEXP 6480464CTD1, 4-bis(2-(3, 5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA], NR1I3 protein promotes the reaction [1, 4-bis(2-(3, 5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]], NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]], Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of UGT1A1 mRNA]

PMID:19196849
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.