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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736633
Species: Homo sapiens
RGD Object: Gene
Symbol: CRP
Name: C-reactive protein
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CRPdecreases expressionEXP 6480464CTDQuercetin results in decreased expression of CRP mRNA; Quercetin results in decreased expression of CRP proteinPMID:17184768
CRPmultiple interactionsEXP 6480464CTD[resveratrol co-treated with pterostilbene co-treated with Quercetin co-treated with tocotrienol, delta co-treated with Niacin] results in decreased expression of CRP protein; Quercetin inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of and results in increased secretion of CRP protein]; Quercetin inhibits the reaction [[IL1B protein co-treated with IL6 protein] results in increased expression of CRP mRNA]; Quercetin inhibits the reaction [IL1B protein results in increased expression of CRP protein]PMID:17388968 PMID:21601209 PMID:24319627
CRPmultiple interactionsISOCrp (Mus musculus)6480464CTDQuercetin inhibits the reaction [perfluorooctanoic acid results in increased expression of CRP protein]PMID:26054880
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