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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735962
Species: Homo sapiens
RGD Object: Gene
Symbol: APOA1
Name: apolipoprotein A1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APOA1decreases expressionEXP 6480464CTDQuercetin results in decreased expression of APOA1 mRNAPMID:25875015
APOA1increases expressionEXP 6480464CTDQuercetin results in increased expression of APOA1 mRNAPMID:24963805
APOA1increases secretionEXP 6480464CTDQuercetin results in increased secretion of APOA1 proteinPMID:24963805
APOA1multiple interactionsEXP 6480464CTDESR1 protein affects the reaction [Quercetin results in increased secretion of APOA1 protein]; fulvestrant inhibits the reaction [Quercetin results in increased secretion of APOA1 protein]PMID:24963805
APOA1multiple interactionsISOApoa1 (Mus musculus)6480464CTD[Glutathione co-treated with Quercetin] promotes the reaction [APOA1 protein results in increased export of Cholesterol]; Quercetin promotes the reaction [APOA1 protein results in increased export of Cholesterol]PMID:25204422
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