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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDQuercetin results in increased expression of NQO1 mRNA, Quercetin results in increased expression of NQO1 protein

PMID:11275421, PMID:21256954, PMID:27454768
multiple interactionsEXP 6480464CTD[pterostilbene co-treated with Quercetin] results in increased expression of NQO1 protein, [Quercetin co-treated with kaempferol] results in increased expression of NQO1 protein, Quercetin inhibits the reaction [Quercetin results in increased expression of NQO1 mRNA], Quercetin results in increased expression of and results in increased activity of NQO1 protein, SB 203580 inhibits the reaction [Quercetin results in increased expression of NQO1 mRNA]

PMID:11275421, PMID:20933534, PMID:21256954, PMID:25111660, PMID:27454768
affects expressionISORGD:25036480464CTDQuercetin affects the expression of NQO1 mRNA

PMID:18178720
increases activityISORGD:104736480464CTDQuercetin analog results in increased activity of NQO1 protein, Quercetin results in increased activity of NQO1 protein

PMID:12628514, PMID:27777014
increases expressionISORGD:104736480464CTDQuercetin results in increased expression of NQO1 mRNA, Quercetin results in increased expression of NQO1 protein

PMID:22334599, PMID:26623679, PMID:29432836
multiple interactionsISORGD:104736480464CTD[Quercetin co-treated with Oxygen] results in increased expression of NQO1 mRNA, [Quercetin co-treated with Oxygen] results in increased expression of NQO1 protein

PMID:29432836
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.