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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735618
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3decreases expressionEXP 6480464CTDQuercetin results in decreased expression of NOS3 mRNAPMID:15740983
NOS3increases expressionEXP 6480464CTDQuercetin results in increased expression of NOS3 mRNAPMID:20021702 PMID:21632981
NOS3multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]; Quercetin inhibits the reaction [Lipids results in decreased expression of NOS3]; Quercetin inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]PMID:16891912 PMID:22902249 PMID:23504962
NOS3decreases expressionISONos3 (Rattus norvegicus)6480464CTDQuercetin results in decreased expression of NOS3 proteinPMID:16331104
NOS3increases expressionISONos3 (Rattus norvegicus)6480464CTDQuercetin results in increased expression of NOS3 proteinPMID:18551111 PMID:22557973
NOS3multiple interactionsISONos3 (Mus musculus)6480464CTD[3,5-dimethoxy-4'-hydroxystilbene co-treated with Quercetin] results in increased expression of NOS3 mRNA; Quercetin inhibits the reaction [APOE gene mutant form results in decreased activity of NOS3 protein]; Quercetin inhibits the reaction [Dietary Fats results in decreased expression of NOS3 mRNA]; Quercetin inhibits the reaction [lead acetate results in decreased expression of NOS3 protein]PMID:17135264 PMID:20093625 PMID:23855546 PMID:27260466
NOS3multiple interactionsISONos3 (Rattus norvegicus)6480464CTD[chelerythrine co-treated with tyrphostin 47] inhibits the reaction [Quercetin results in increased expression of NOS3 protein]; Quercetin inhibits the reaction [INS1 protein results in increased phosphorylation of NOS3 protein]; Quercetin inhibits the reaction [Monocrotaline results in decreased expression of NOS3 mRNA]; Quercetin promotes the reaction [Cadmium results in increased expression of NOS3 mRNA]; Quercetin promotes the reaction [Cadmium results in increased expression of NOS3 protein]PMID:16226777 PMID:19903466 PMID:22557973 PMID:25460361
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