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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735541
Species: Homo sapiens
RGD Object: Gene
Symbol: BAD
Name: BCL2 associated agonist of cell death
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BADdecreases phosphorylationEXP 6480464CTDQuercetin results in decreased phosphorylation of BAD proteinPMID:18455702 PMID:20438634
BADincreases expressionEXP 6480464CTDQuercetin results in increased expression of BAD mRNA; Quercetin results in increased expression of BAD proteinPMID:14688022 PMID:14767529 PMID:20658310 PMID:25339540 PMID:30152185 PMID:30639267
BADmultiple interactionsEXP 6480464CTD[Quercetin analog co-treated with Gold analog] results in increased expression of BAD protein; Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of BAD protein]; Quercetin promotes the reaction [BCL2L1 protein binds to BAD protein]PMID:18455702 PMID:25380086 PMID:27470402
BADdecreases phosphorylationISOBad (Mus musculus)6480464CTDQuercetin results in decreased phosphorylation of BAD proteinPMID:12826665
BADmultiple interactionsISOBad (Rattus norvegicus)6480464CTDQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of BAD mRNA]PMID:26476374
BADmultiple interactionsISOBad (Mus musculus)6480464CTDQuercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of BAD protein]PMID:27494022
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