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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735336
Species: Mus musculus
RGD Object: Gene
Symbol: Akt1
Name: thymoma viral proto-oncogene 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akt1decreases expressionEXP 6480464CTDQuercetin results in decreased expression of AKT1 mRNA; Quercetin results in decreased expression of AKT1 proteinPMID:25658812
Akt1decreases phosphorylationEXP 6480464CTDQuercetin results in decreased phosphorylation of AKT1 proteinPMID:22850125
Akt1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid results in decreased phosphorylation of AKT1 protein]]; [dorsomorphin co-treated with Quercetin] inhibits the reaction [[TNF protein co-treated with INS1 protein] results in decreased expression of AKT1 protein]; [Quercetin co-treated with Catechin] results in increased phosphorylation of AKT1 protein; [Quercetin co-treated with Hydrogen Peroxide] results in decreased expression of AKT1 protein; acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Quercetin affects the expression of AKT1 protein]; Quercetin affects the expression of and results in decreased phosphorylation of AKT1 protein; Quercetin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [[TNF protein co-treated with INS1 protein] results in decreased expression of AKT1 protein]; Quercetin inhibits the reaction [Dietary Fats results in decreased expression of AKT1 mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Okadaic Acid results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [TNF protein inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]]; Quercetin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]PMID:12826665 PMID:17449583 PMID:18720166 PMID:20060843 PMID:22850125 PMID:23439570 PMID:23735482 PMID:24353828 PMID:26363153 PMID:27050422 PMID:27260466 PMID:27494022
Akt1affects phosphorylationISOAKT1 (Homo sapiens)6480464CTDQuercetin affects the phosphorylation of AKT1 proteinPMID:24001813
Akt1decreases expressionISOAKT1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of AKT1 mRNA; Quercetin results in decreased expression of AKT1 protein; Quercetin results in decreased expression of AKT1 protein modified formPMID:12653748 PMID:23727915 PMID:24299158 PMID:38134066
Akt1decreases phosphorylationISOAKT1 (Homo sapiens)6480464CTDQuercetin results in decreased phosphorylation of AKT1 proteinPMID:12888923 PMID:15741050 PMID:15829497 PMID:16082193 PMID:16794257 PMID:17973296 PMID:18655187 PMID:19344998 PMID:20386985 PMID:20438634 PMID:20658310 PMID:22555976 PMID:23094058 PMID:23353698 PMID:25380086 PMID:26011145 PMID:38134066
Akt1increases expressionISOAKT1 (Homo sapiens)6480464CTDQuercetin results in increased expression of AKT1 mRNAPMID:14715546
Akt1increases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDQuercetin results in increased phosphorylation of AKT1 proteinPMID:17045724
Akt1increases phosphorylationISOAKT1 (Homo sapiens)6480464CTDQuercetin results in increased phosphorylation of AKT1 proteinPMID:24275163 PMID:26986492 PMID:37690812
Akt1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]]; [Quercetin co-treated with Tretinoin] affects the phosphorylation of AKT1 protein; NGF protein inhibits the reaction [Quercetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]]; Quercetin affects the reaction [Monocrotaline affects the expression of and affects the phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [[Hydrogen Peroxide co-treated with Tretinoin] results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of and results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Fructose results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of AKT1 mRNA]; Quercetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [TNF protein inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]]; Quercetin inhibits the reaction [Vincristine results in decreased expression of AKT1 mRNA]; Quercetin promotes the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]PMID:11306697 PMID:17045724 PMID:17962351 PMID:19903466 PMID:20377179 PMID:20685402 PMID:21803128 PMID:22426011 PMID:22713545 PMID:23533474 PMID:25164625 PMID:25203460 PMID:25460361 PMID:26476374 PMID:33038355 PMID:37566541
Akt1multiple interactionsISOAKT1 (Homo sapiens)6480464CTD2-methoxyestradiol inhibits the reaction [Quercetin results in decreased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] results in decreased phosphorylation of AKT1 protein; [epigallocatechin gallate co-treated with Quercetin] promotes the reaction [docetaxel results in decreased phosphorylation of AKT1 protein]; [epigallocatechin gallate co-treated with Quercetin] results in decreased phosphorylation of AKT1 protein; [Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of AKT1 protein; [Quercetin co-treated with 2-methoxyestradiol] results in decreased phosphorylation of AKT1 protein; [Quercetin co-treated with arctigenin] results in decreased expression of AKT1 protein; AKT1 protein inhibits the reaction [Quercetin results in decreased expression of BCL2 protein]; AKT1 protein inhibits the reaction [Quercetin results in increased cleavage of PARP1 protein]; AKT1 protein inhibits the reaction [Quercetin results in increased expression of BAX protein]; AKT1 protein modified form inhibits the reaction [Quercetin affects the localization of RELA protein]; AKT1 protein modified form inhibits the reaction [Quercetin results in decreased phosphorylation of CHUK protein]; arctigenin promotes the reaction [Quercetin results in decreased phosphorylation of AKT1 protein]; Cisplatin promotes the reaction [Quercetin results in decreased phosphorylation of AKT1 protein]; docetaxel promotes the reaction [[epigallocatechin gallate co-treated with Quercetin] results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [2-methoxyestradiol results in decreased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Quercetin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [HGF protein results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [TGFA protein results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of AKT1 protein]; Quercetin results in decreased activity of and results in decreased phosphorylation of AKT1 protein; Quercetin results in decreased expression of and results in decreased phosphorylation of AKT1 proteinPMID:12888923 PMID:14688022 PMID:16082193 PMID:16619521 PMID:18359480 PMID:18455702 PMID:19244381 PMID:19464278 PMID:20153296 PMID:20386985 PMID:20438634 PMID:20658310 PMID:23094058 PMID:25380086 PMID:25655047 PMID:26011145 PMID:27470402
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