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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732953
Species: Mus musculus
RGD Object: Gene
Symbol: Slc22a8
Name: solute carrier family 22 (organic anion transporter), member 8
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a8affects expressionISOSlc22a8 (Rattus norvegicus)6480464CTDQuercetin affects the expression of SLC22A8 proteinPMID:24958931
Slc22a8decreases activityISOSLC22A8 (Homo sapiens)6480464CTDQuercetin results in decreased activity of SLC22A8 proteinPMID:32159797
Slc22a8multiple interactionsISOSLC22A8 (Homo sapiens)6480464CTDQuercetin inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]PMID:19605544
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