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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732227
Species: Homo sapiens
RGD Object: Gene
Symbol: NR3C1
Name: nuclear receptor subfamily 3 group C member 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR3C1decreases expressionEXP 6480464CTDQuercetin results in decreased expression of NR3C1PMID:8745575
NR3C1increases expressionEXP 6480464CTDQuercetin results in increased expression of NR3C1 mRNAPMID:21632981
NR3C1affects activityISONr3c1 (Mus musculus)6480464CTDQuercetin affects the activity of NR3C1 proteinPMID:10590836
NR3C1affects activityISONr3c1 (Rattus norvegicus)6480464CTDQuercetin affects the activity of NR3C1 proteinPMID:19423323
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