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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730903
Species: Homo sapiens
RGD Object: Gene
Symbol: CCND2
Name: cyclin D2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCND2decreases expressionEXP 6480464CTDQuercetin results in decreased expression of CCND2 mRNAPMID:14715546
CCND2multiple interactionsEXP 6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of CCND2 mRNA; [Quercetin co-treated with Ascorbic Acid] results in increased expression of CCND2 mRNAPMID:17639512 PMID:27514524
CCND2decreases expressionISOCcnd2 (Mus musculus)6480464CTDQuercetin results in decreased expression of CCND2 mRNAPMID:22185406
CCND2multiple interactionsISOCcnd2 (Mus musculus)6480464CTDQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCND2 mRNA]PMID:22185406
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