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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein], Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA], Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]

PMID:23647015
increases expressionISORGD:694736480464CTDQuercetin results in increased expression of SREBF1 mRNA

PMID:21632981
multiple interactionsISORGD:694736480464CTDQuercetin inhibits the reaction [[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 mRNA], Quercetin inhibits the reaction [[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 protein], Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein]

PMID:23647015, PMID:24648896
multiple interactionsISORGD:694746480464CTDQuercetin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 protein], Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA], Quercetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

PMID:18586010, PMID:21462320, PMID:24025686
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.