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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF1 mRNA]; Quercetin inhibits the reaction [Streptozocin results in increased expression of SREBF1 protein]PMID:23647015
Srebf1increases expressionISOSREBF1 (Homo sapiens)6480464CTDQuercetin results in increased expression of SREBF1 mRNAPMID:21632981
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTDQuercetin inhibits the reaction [[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 mRNA]; Quercetin inhibits the reaction [[Fatty Acids co-treated with INS protein] results in increased expression of SREBF1 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein]PMID:23647015 PMID:24648896
Srebf1multiple interactionsISOSrebf1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SREBF1 protein]; Quercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in increased expression of SREBF1 mRNA]; Quercetin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]PMID:18586010 PMID:21462320 PMID:24025686
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