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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69096
Species: Mus musculus
RGD Object: Gene
Symbol: Tgfb1
Name: transforming growth factor, beta 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgfb1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Quercetin promotes the reaction [[Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK1 protein]; Quercetin promotes the reaction [[Propylene Glycol co-treated with TGFB1 protein] results in increased phosphorylation of MAPK3 protein]; Quercetin promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; Quercetin promotes the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; tin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]PMID:21216973 PMID:22902988
Tgfb1decreases expressionISOTgfb1 (Rattus norvegicus)6480464CTDQuercetin results in decreased expression of TGFB1 mRNAPMID:15573758 PMID:27601294
Tgfb1decreases expressionISOTGFB1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of TGFB1 mRNA; Quercetin results in decreased expression of TGFB1 proteinPMID:17086741 PMID:23727915 PMID:33070227
Tgfb1increases expressionISOTgfb1 (Rattus norvegicus)6480464CTDQuercetin results in increased expression of TGFB1 mRNAPMID:26136938
Tgfb1increases expressionISOTGFB1 (Homo sapiens)6480464CTDQuercetin results in increased expression of TGFB1 mRNAPMID:21632981
Tgfb1increases secretionISOTGFB1 (Homo sapiens)6480464CTDQuercetin results in increased secretion of TGFB1 proteinPMID:7780149 PMID:8157359
Tgfb1multiple interactionsISOTgfb1 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of TGFB1 mRNA]; Quercetin analog inhibits the reaction [sodium arsenite results in increased expression of TGFB1 protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Quercetin inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 protein]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; Quercetin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein]; Quercetin inhibits the reaction [Oxygen deficiency results in increased expression of TGFB1 mRNA]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]PMID:12580099 PMID:12956909 PMID:15573758 PMID:19474275 PMID:20371363 PMID:22989100 PMID:24117263 PMID:26136938 PMID:26476374 PMID:34922902
Tgfb1multiple interactionsISOTGFB1 (Homo sapiens)6480464CTD[Quercetin co-treated with Ascorbic Acid] results in increased expression of TGFB1 mRNA; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; SHH protein inhibits the reaction [Quercetin results in decreased expression of TGFB1 protein]PMID:17639512 PMID:21216973 PMID:22871832 PMID:33070227
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