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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgm2
Name: transglutaminase 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgm2multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of and results in increased activity of TGM2 protein]; Quercetin inhibits the reaction [Warfarin results in increased activity of TGM2 protein]PMID:23117658
Tgm2affects response to substanceISOTgm2 (Mus musculus)6480464CTD[TGM2 protein affects the susceptibility to Warfarin] which affects the susceptibility to QuercetinPMID:23117658
Tgm2multiple interactionsISOTGM2 (Homo sapiens)6480464CTDQuercetin binds to and results in decreased activity of TGM2 proteinPMID:23117658
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