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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ephx2
Name: epoxide hydrolase 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ephx2decreases expressionEXP 6480464CTDQuercetin results in decreased expression of EPHX2 mRNAPMID:17103110
Ephx2increases expressionEXP 6480464CTDQuercetin results in increased expression of EPHX2 mRNAPMID:18095365
Ephx2decreases activityISOEphx2 (Mus musculus)6480464CTDQuercetin results in decreased activity of EPHX2 proteinPMID:3621371
Ephx2multiple interactionsISOEPHX2 (Homo sapiens)6480464CTD[Quercetin co-treated with Ascorbic Acid] results in decreased expression of EPHX2 mRNAPMID:17639512
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