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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61817
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col1a1
Name: collagen type I alpha 1 chain
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1decreases expressionEXP 6480464CTDQuercetin results in decreased expression of COL1A1 mRNAPMID:11749858 PMID:27601294
Col1a1increases expressionEXP 6480464CTDQuercetin results in increased expression of COL1A1 mRNAPMID:26053266
Col1a1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Quercetin results in increased expression of COL1A1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Quercetin results in increased expression of COL1A1 mRNA]; Quercetin analog inhibits the reaction [sodium arsenite results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [Warfarin results in increased expression of COL1A1 mRNA]PMID:12580099 PMID:20371363 PMID:23117658 PMID:23223575 PMID:26053266
Col1a1decreases expressionISOCOL1A1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of COL1A1 mRNAPMID:22871832
Col1a1multiple interactionsISOCol1a1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; tin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]PMID:21216973 PMID:22915297 PMID:27601294
Col1a1multiple interactionsISOCOL1A1 (Homo sapiens)6480464CTDQuercetin inhibits the reaction [DEFA1 protein results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [DEFA1 protein results in increased secretion of COL1A1 protein]; Quercetin inhibits the reaction [DEFA2 protein results in increased expression of COL1A1 mRNA]; Quercetin inhibits the reaction [DEFA2 protein results in increased secretion of COL1A1 protein]; Quercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]PMID:19814765 PMID:21216973 PMID:22871832
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