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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3130
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Myc
Name: MYC proto-oncogene, bHLH transcription factor
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycdecreases expressionISOMYC (Homo sapiens)6480464CTDQuercetin results in decreased expression of MYC mRNA; Quercetin results in decreased expression of MYC proteinPMID:15670774 PMID:16948901 PMID:21632981 PMID:22245592 PMID:23727915 PMID:33070227 PMID:9381980
Mycincreases expressionISOMYC (Homo sapiens)6480464CTDQuercetin results in increased expression of MYC mRNAPMID:15309432
Mycmultiple interactionsISOMYC (Homo sapiens)6480464CTD[Quercetin results in increased activity of SIRT1 protein] which results in decreased expression of MYC proteinPMID:22245592
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