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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2323
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn2a
Name: cyclin-dependent kinase inhibitor 2A
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2amultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Doxorubicin results in increased expression of CDKN2A protein alternative form]; Quercetin inhibits the reaction [Doxorubicin results in increased expression of CDKN2A protein]PMID:24902966
Cdkn2adecreases expressionISOCDKN2A (Homo sapiens)6480464CTDQuercetin results in decreased expression of CDKN2A mRNAPMID:23727915
Cdkn2adecreases methylationISOCDKN2A (Homo sapiens)6480464CTDQuercetin results in decreased methylation of CDKN2A promoterPMID:18974642
Cdkn2aincreases expressionISOCDKN2A (Homo sapiens)6480464CTDQuercetin results in increased expression of CDKN2A mRNA; Quercetin results in increased expression of CDKN2A proteinPMID:28251795 PMID:36982678
Cdkn2amultiple interactionsISOCDKN2A (Homo sapiens)6480464CTD[bisphenol A co-treated with Quercetin metabolite] results in decreased expression of CDKN2A mRNA; [Cisplatin co-treated with Quercetin] results in increased expression of CDKN2A mRNAPMID:27514524 PMID:36982678
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