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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2153
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Arnt
Name: aryl hydrocarbon receptor nuclear translocator
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Arntdecreases expressionISOARNT (Homo sapiens)6480464CTDQuercetin results in decreased expression of ARNT mRNAPMID:21256954
Arntincreases localizationISOARNT (Homo sapiens)6480464CTDQuercetin results in increased localization of ARNT proteinPMID:21756928
Arntmultiple interactionsISOARNT (Homo sapiens)6480464CTDQuercetin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of ARNT protein]; Quercetin promotes the reaction [Benzo(a)pyrene results in decreased expression of ARNT mRNA]PMID:21256954 PMID:21756928
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