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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1616012
Species: Mus musculus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle, aorta
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of ACTA2 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]PMID:22915297 PMID:27601294
Acta2decreases expressionISOACTA2 (Homo sapiens)6480464CTDQuercetin results in decreased expression of ACTA2 mRNA; Quercetin results in decreased expression of ACTA2 proteinPMID:33070227
Acta2decreases expressionISOActa2 (Rattus norvegicus)6480464CTDQuercetin results in decreased expression of ACTA2 mRNA; Quercetin results in decreased expression of ACTA2 proteinPMID:27601294 PMID:9581680
Acta2increases expressionISOACTA2 (Homo sapiens)6480464CTDQuercetin results in increased expression of ACTA2 mRNAPMID:21632981
Acta2increases expressionISOActa2 (Rattus norvegicus)6480464CTDQuercetin results in increased expression of ACTA2 mRNAPMID:23117658
Acta2multiple interactionsISOACTA2 (Homo sapiens)6480464CTDQuercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; SHH protein inhibits the reaction [Quercetin results in decreased expression of ACTA2 protein]PMID:22871832 PMID:33070227
Acta2multiple interactionsISOActa2 (Rattus norvegicus)6480464CTD[Warfarin co-treated with Vitamin K co-treated with Quercetin] results in increased expression of ACTA2 mRNA; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Quercetin inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]PMID:12956909 PMID:22989100 PMID:23117658
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