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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604657
Species: Homo sapiens
RGD Object: Gene
Symbol: CD40
Name: CD40 molecule
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CD40multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein]; Quercetin inhibits the reaction [[CD40LG protein co-treated with CD40 protein] inhibits the reaction [EIF4E protein binds to EIF4EBP1 protein]]PMID:15611226 PMID:16601352
CD40increases expressionISOCd40 (Mus musculus)6480464CTDQuercetin results in increased expression of CD40 mRNAPMID:22185406
CD40multiple interactionsISOCd40 (Mus musculus)6480464CTDQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]; Quercetin inhibits the reaction [TLR7 protein affects the localization of CD40 protein]; Quercetin inhibits the reaction [TLR7 protein results in increased expression of CD40]PMID:22185406 PMID:26329008
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