Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593284
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspa1a
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspa1aaffects expressionISOHspa1a (Mus musculus)6480464CTDQuercetin affects the expression of HSPA1A proteinPMID:14606951
Hspa1adecreases expressionISOHSPA1A (Homo sapiens)6480464CTDQuercetin results in decreased expression of HSPA1A mRNA; Quercetin results in decreased expression of HSPA1A proteinPMID:17234771 PMID:21632981
Hspa1adecreases expressionISOHspa1a (Mus musculus)6480464CTDQuercetin results in decreased expression of HSPA1A mRNAPMID:17349211
Hspa1aincreases expressionISOHSPA1A (Homo sapiens)6480464CTDQuercetin results in increased expression of HSPA1A proteinPMID:14750173
Hspa1aincreases response to substanceISOHSPA1A (Homo sapiens)6480464CTDHSPA1A mutant form results in increased susceptibility to QuercetinPMID:24126416
Hspa1amultiple interactionsISOHSPA1A (Homo sapiens)6480464CTD[Quercetin co-treated with Ascorbic Acid] results in increased expression of HSPA1A mRNA; HSPA1A mutant form results in increased susceptibility to [Quercetin co-treated with temozolomide]PMID:17639512 PMID:24126416
Hspa1amultiple interactionsISOHspa1a (Mus musculus)6480464CTDQuercetin inhibits the reaction [Hydrogen Peroxide affects the localization of HSPA1A protein]; Quercetin inhibits the reaction [Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein]]; Quercetin inhibits the reaction [sodium arsenite results in increased expression of HSPA1A protein]PMID:14606951 PMID:17513788
Go Back to source page   Continue to Ontology report