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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axmultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]PMID:24902966
H2axincreases expressionISOH2ax (Mus musculus)6480464CTDQuercetin results in increased expression of H2AX proteinPMID:24595819
H2axincreases phosphorylationISOH2AX (Homo sapiens)6480464CTDQuercetin results in increased phosphorylation of H2AX proteinPMID:15177039
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTDQuercetin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]PMID:24999622
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