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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350637
Species: Homo sapiens
RGD Object: Gene
Symbol: TOP2B
Name: DNA topoisomerase II beta
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TOP2Bdecreases expressionEXP 6480464CTDQuercetin results in decreased expression of TOP2B mRNA

PMID:21632981
TOP2Bmultiple interactionsISORGD:15861566480464CTDQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of TOP2B mRNA]

PMID:26476374
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