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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347922
Species: Homo sapiens
RGD Object: Gene
Symbol: PCK1
Name: phosphoenolpyruvate carboxykinase 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PCK1decreases expressionEXP 6480464CTDQuercetin results in decreased expression of PCK1 mRNAPMID:21632981
PCK1increases expressionISOPck1 (Rattus norvegicus)6480464CTDQuercetin results in increased expression of PCK1 mRNAPMID:21565894
PCK1multiple interactionsISOPck1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PCK1 mRNA]PMID:21462320
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