GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2c65 | decreases activity | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | Quercetin results in decreased activity of CYP2C9 protein | PMID:18420780 PMID:29753067 | Cyp2c65 | increases expression | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | Quercetin results in increased expression of CYP2C9 mRNA | PMID:21632981 | Cyp2c65 | multiple interactions | ISO | CYP2C9 (Homo sapiens) | 6480464 | CTD | Quercetin inhibits the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Quercetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] | PMID:21053930 PMID:24120545 | |
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